In mice vaccination with Streptococcus pneumoniae results in an increase in anti-oxLDL IgM\nantibodies due to mimicry of anti-phosphorylcholine (present in the cell wall of S. pneumoniae) and\nanti-oxLDL IgM. In this study we investigated the human translation of this molecular mimicry\nby vaccination against S. pneumoniae using the Prevenar-13 vaccine. Twenty-four healthy male\nvolunteers were vaccinated with Prevenar-13, either three times, twice or once in a double-blind,\nplacebo-controlled, randomized single center clinical study. Anti-pneumococcal wall, oxLDL and\nphosphorycholine antibody levels were measured at a fixed serum dilution, as well as circulating\nlipid levels over the course of 68 weeks. A significant increase in anti-oxLDL IgG and IgM was seen in\nthe group receiving two doses six months apart compared to the placebo. However, these differences\nwere not observed in the groups receiving a single dose, two doses one month apart, or three doses.\nThis study shows that vaccination.........................
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